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Statin medication use and the risk of biochemical recurrence after radical prostatectomy Cancer, 07/01/10

Hamilton RJ et al. – In this cohort of men undergoing RP, statin use was associated with a dose-dependent reduction in the risk of biochemical recurrence. If confirmed in other studies, these findings suggest statins may slow PC progression after R

Methods

  • Examined 1319 men treated with RP from the Shared Equal Access Regional Cancer Hospital (SEARCH) Database
  • Time to PSA recurrence was compared between users and nonusers of statin at surgery using Cox proportional hazards models adjusted for multiple clinical and pathological feature

Many randomised controlled trials have investigated the effect of adjuvant chemotherapy in operable non-small-cell lung cancer. We undertook two comprehensive systematic reviews and meta-analyses to establish the effects of adding adjuvant chemotherapy to surgery, or to surgery plus radiotherapy. The addition of adjuvant chemotherapy after surgery for patients with operable non-small-cell lung cancer improves survival.

Read the free abstract at the journal's web site

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1 Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: Two meta-analyses of individual patient data - 100% The Lancet, June 10, 2010

2 Adjuvant chemotherapy use and adverse events among older patients with stage III colon cancer - 96% JAMA, May 14, 2010

3 Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: Two meta-analyses of individual patient data - 96% The Lancet - Early Online Publication, May 21, 2010

4 Treatment results of FOLFOX chemotherapy before surgery for lymph node metastasis of advanced colorectal cancer with synchronous liver metastasis: the status of LN metastasis and vessel invasions at the primary site in patients who responded to FOLFOX - 92% International Journal of Clinical Oncology, March 28, 2010

5 Sequential chemotherapy and intensity-modulated radiation therapy in the management of locoregionally advanced nasopharyngeal carcinoma: Experience of 370 consecutive cases - 90% BMC Cancer, April 16, 2010

6 Changes in markers of ovarian reserve and endocrine function in young women with breast cancer undergoing adjuvant chemotherapy - 81% Cancer, April 28, 2010

7 Clinicopathological variables predictive of clinical outcome in patients with figo stage IB2-IIb cervical cancer treated with cisplatin-based neoadjuvant chemotherapy followed by radical hysterectomy - 78% Anticancer Research, April 16, 2010

8 Pancreatic proteolytic enzyme therapy compared with gemcitabine-based chemotherapy for the treatment of pancreatic cancer - 77% Journal of Clinical Oncology, May 7, 2010

9 Surgery with or without preoperative paclitaxel and carboplatin in early-stage non-small-cell lung cancer: Southwest Oncology Group Trial s9900, an intergroup, randomized, phase III trial - 77% Journal of Clinical Oncology, May 15, 2010

10 Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer - 73% Cochrane Reviews, April 2, 2010

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